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La Bio-Impédancemétrie Spectroscopique (BIS)
La précision scientifique au service de votre officine !
LA TECHNOLOGIE
What is spectroscopic bioimpedancemetry (BIS)?
Spectroscopic bioimpedancemetry (BIS) is a body composition analysis technique based on the electrical properties of biological tissues.
Contrairement à la bioimpédance mono-fréquence classique, la BIS s’appuie sur un spectre large (1–1000 kHz), et n’utilise pas de méthode déductive basée sur des moyennes populationnelles : chaque mesure est individuelle et spécifique, sans extrapolation à partir de l’âge, du sexe ou d’indices standards comme l’IMC.
UNE LECTURE PLUS FINE
Body composition, beyond weight and BMI
Le suivi clinique moderne ne peut plus se limiter au poids et à l’indice de masse corporelle (IMC). Ces deux mesures, bien que simples, n’informent en rien sur la répartition réelle des compartiments corporels. Un IMC « normal » peut masquer une sarcopénie ou une dénutrition, tandis qu’un IMC élevé ne distingue pas une surcharge adipeuse d’une forte masse musculaire.
The 5-compartment modelling used in VitaScan offers a much more detailed and relevant reading:
- Body fat
- (LF)Lean mass
- (MM)Water
- Intracellulaire (ICW)
- Extracellular water (ECW)
- Bone mineral content (BMC)
This compartmentalized monitoring can reveal imbalances invisible through weight alone. For example, muscle loss masked by fluid retention in a person suffering from heart failure.
EN PRATIQUE
Comprendre la technologie derrière Vitascan
Physical principle and models used
Un courant alternatif de très faible intensité (environ 70 μA), totalement indolore, traverse les différents tissus du corps via quatre électrodes sources placées sur les mains et les pieds.
Le courant circule principalement dans les tissus les plus conducteurs, comme l’eau, les électrolytes et les muscles, tandis que les tissus moins conducteurs à basse fréquence, comme la masse grasse, les membranes cellulaires et la peau, y résistent davantage. C’est la bio-impédance.
A voltage is measured at the receiving electrodes. This voltage is broken down into two components:
The combination of these two values forms the impedance (Z), which varies according to the frequency applied.
Des indicateurs clairs
The measurements collected are transformed into physiological indicators using several complementary models:
- Generalized Ohm's law (U = Z × I) to link voltage and current.
- Mixed model (spectroscopic impedance) analyses impedance evolution over the entire frequency spectrum.
- Empirical model (regression equations) used to refine certain clinical correlations.
- Biophysical model (Cole circuit): graphic representation of tissue behavior, integrating resistance and membrane capacity.
EN PRATIQUE
Why does multi-frequency change everything?
The spectroscopic bioimpedancemetry (BIS) uses a frequency spectrum from 1 to 1000 kHz, unlike single-frequency bioimpedance, which is often limited to 50 kHz. A wider frequency spectrum enables more accurate measurement of the indicators:
The combination of these data makes it possible to evaluate data with an accuracy impossible to achieve with a single frequency:
- La répartition hydrique
- La vitalité cellulaire (via l’angle de phase)
- L’hydratation de la massage non grasse
- La santé métabolique globale
EVOLUTION DU métier
Une nouvelle génération d’impédancemètres, la non-déductivité
La majorité des impédancemètres du marché fonctionnent selon un principe déductif : les mesures électriques sont intégrées à des équations de régression calibrées sur des populations « normo-hydratées ». Ces modèles peuvent introduire des biais dès que le patient s’éloigne de la moyenne : obésité, dénutrition, insuffisance rénale ou pathologies cardiovasculaires.
Une masse maigre peut ainsi être surestimée chez un patient sarcopénique présentant une rétention d’eau.
La technologie développée par Bioparhom et utilisée dans VitaScan repose au contraire sur une approche non déductive :
- Chaque compartiment tissulaire et hydrique est mesuré indépendamment, sans coefficients fixes.
- Les équations sont validées cliniquement par comparaison à des méthodes de référence, comme la DEXA et Xitron.
- L’erreur moyenne est inférieure à 3,5 %, offrant une précision adaptée au suivi médical longitudinal.
Cette technologie permet ainsi de mesurer les compartiments physiologiques avec précision, plutôt que de les estimer.
NOS CERTIFICATIONS
Des preuves cliniques solides
Assessment of Food Intake Assisted by Photography in Older People Living in a Nursing Home: Maintenance over Time and Performance for Diagnosis of Malnutrition
Billeret A., Rousseau C., Thirion R., Baillard-Cosme B., Charras K., Somme D., & Thibault R. - Nutrients, 2023, vol. 15, no 3, p. 646
Implementation of new undernutrition criteria: variability of coding factors and consequences
Berera T., Chiarot C., Grandjean F., Gorcy S. - JFN, 2022, book of abstracts, p. 163
L’impédancemétrie dans une population d’anorexique mentale: développement d’un outil validé pour une population avec IMC < 18 ?
Ronin C. et Fontaine E. – Nutrition Clinique et Métabolisme, 2020, vol. 34, no 1, p. 40
Sustainable modification of lifestyle habits through physical activity in the fight against obesity in adults: presentation of the feasibility protocol
Dumoulin C., Reynes E., and Berthouze S. - Obésité, 2017, vol. 12, no. 4, p. 291-296
New method for quantifying total water volume in the obese subject
Moreno M.-V., Coux M.-N., Cornet E., Goyard E. - JFN, 2016
Total albumin index: nutritional marker of albumin pool variations in clinical practice
Picot D., Bollart A.-S., Layec S., et al - Nutrition Clinique et Métabolisme, 2016, vol. 30, no. 2, p. 115
Validation of a Hypgnomagnetiism method for thinning
Ribbe E., Vannicatte A., Moreno M.-V. - Gazz Med Ital-Arch SCI Med, 2015; 174:1-2;3112-GMI
Optimizing nutritional strategy with body composition
Coux M.-N., Ribbe E., Moreno M.-V. - Nutrition Clinique et Métabolisme, 2014, vol. 28 (supplement), p. S90-91
Optimizing nutritional strategy through body composition
Coux M.-N., Ribbe E., Moreno M.-V. - Intelligent Health & Preventive Medicine International Symposium, Tangier, June 2014
Body composition differences between healthy, obese and anorexic children
Dassonville Y., Ribbe E., Moreno M.-V., Clarion A., Malcor S. - ICEBI, Procedia, 2013, p. 207
A phase 2 randomized trial to evaluate the impact of a supervised exercise program on cardiotoxicity at 3 months in patients with HER2 overexpressing breast cancer undergoing adjuvant treatment by trastuzumab: design of the CARDAPAC study
Jacquinot Q., Meneveau N., Chatot M., et al. BMC Cancer, 2017, vol. 17, no. 1, p. 425
Comparison of two methods of body composition (BC) assessment in patients followed for cancer: multi-frequency impedancemetry (BIS) and CT image analysis
Hollebecque A., Cousin S., Ribbe E., Moreno M.-V., Clarion A., Varga A., Soria J.-C., Antoun S. Nutrition Clinique et Métabolisme, 2012, vol. 26, S54
Loss of lean body mass and hydration are independent predictors of loss of autonomy. A multicenter study has shown that BIS monitoring can be used to adapt SSR management and reduce prolonged hospitalization.
(Turk S et AL., Variation in weight, body composition/phase angle and grip strength during the first 3 weeks of hospitalization in geriatric SSR. Multicenter prospective study, 2022)
Variation in weight, body composition/phase angle and grip strength during the first 3 weeks of hospitalization in geriatric SSR. Prospective multicenter study
Turk S., Bouillanne O., Petiot L., Aussel C., Levy P., Forasassi C. Nutrition Clinique et Métabolisme, 2022, vol. 36, no 1, p. S47
GNRI, variation in body composition and mortality in elderly subjects hospitalized in geriatric SSR
Petiot L., Levy P., Bouillanne O., Aussel C., Turk S., Forasassi C. Journées Francophones de Nutrition, 2021, P109
Effects of a home-based physical activity incentive and education program in subacute post-stroke patients on 6-minute walk test performance
Chaparro D. PhD Thesis, University of Limoges, 2018
Description of physiological aging process and detection of malnutrition through the study of body composition determined by bioimpedance
Portail A., Ribbe E., Coux M.-N., Moreno M.-V. Gazzetta Medica Italiana Archivio per le Scienze Mediche, 2017, vol. 176, no. 7-8, pp. 369-376
Evolution of body composition with age according to bioimpedance
Moreno M.-V., Ribbe E., Portail A. 2ᵉ Symposium International Neutraceutique et Environnement Santé, 2011
Assessment of muscle ageing and the value of physical activity
Moreno M.-V., Ribbe E., Rebeyrol J., Khider N., Portail A. 2ᵉ International Symposium Neutraceuticals and Environment Health, 2011
In dialysis patients, BIS helps adjust dry weight with a better correlation to actual fluid overload. *
In chronic renal failure, it enables early detection of water imbalances. **
* Bataille, S., et Al, (2017). The diagnosis of sarcopenia is mainly driven by muscle mass in hemodialysis patients.
** Florent Guerville, Composition corporelle estimée par bio-impédancemétrie spectroscopique au cours de la maladie rénale chronique stade 3 à 5; thèse médecine, 2014
-
Myostatin and Insulin-Like Growth Factor 1 Are Biomarkers of Muscle Strength, Muscle Mass, and Mortality in Patients on Hemodialysis
Delanaye P., Bataille S., Quinonez K., et al. Journal of Renal Nutrition, 2019
The diagnosis of sarcopenia is mainly driven by muscle mass in hemodialysis patients
Bataille S., Serveaux M., Carreno E., et al. Clinical Nutrition, 2017, vol. 36, no 6, p. 1654-1660
Haemodialysis patients with diabetes eat less than those without: A plea for a permissive diet
Bataille S., Landrier J.-F., Astier J., et al. Nephrology, 2017, vol. 22, no. 9, pp. 712-719
Prevalence and diagnostic approach to sarcopenia in the chronic hemodialysis patient
Bataille S., Serveaux M., Robert A. Nephrology & Therapeutics, 2016, vol. 12, no. 5, p. 267-268
The Complicating Effects of Patient Limb Position on the Development of a Localised Impedimetric-Based Hydrational Index for the Remote Monitoring of Home-Based Dialysis Patients
Montalibet A., Arkouche W., Franco P., Bogonez, et al. IRBM, 2016, vol. 37, no 2, p. 58-67
Plasma 25-OH vitamin D concentration independently correlates with muscle strength in hemodialysis patients
Bataille S., Landrier J.-F., Astier J., et al. Nephrology & Therapeutics, 2015, vol. 11, no. 5, p. 323
The "Dose-Effect" Relationship Between 25-Hydroxyvitamin D and Muscle Strength in Hemodialysis Patients Favors a Normal Threshold of 30 ng/mL for Plasma 25-Hydroxyvitamin D
Bataille S., Landrier J.-F., Astier J., et al. Journal of Renal Nutrition, 2016, vol. 26, no. 1, p. 45-52
Body composition estimated by spectroscopic bioimpedancemetry during stage 3 to 5 chronic kidney disease
Guerville F. Thesis of Medicine, DUMAS-00968205, 2014
Fat-free mass at admission predicts 28-day mortality in intensive care unit patients: the international prospective observational study Phase Angle Project
Thibault R., Makhlouf A.-M., Mulliez A., et al. Intensive Care Medicine, 2016, vol. 42, no. 9, pp. 1445-1453
Accuracy of water compartment measurement by bioimpedancemetry during a filling test in intensive care: a prospective observational study
Champion S., Dewitte A., Carles P., Joannes-Boyau O., Megret F., Fleureau C., Ouattara A. 42nd Congress of French Language Resuscitation, 2013
Decreased phase angle measured by bioimpedance is associated with mortality and severity of illness in the ICU
Thibault R., Perbet S., Wang Z., Pereira B., Cano N., Constantin J.-M. Nutrition Clinique et Métabolisme, 2012, vol. 26, S48
Cardiac repercussions of adolescent weight disorders: Evaluation of left ventricular mechanics and myocardial work
Paysal J. Doctoral thesis, University of Avignon
Effect of individualized coaching at home on walking capacity in subacute stroke patients: A randomized controlled trial (Ticaa'dom)
Mandigout S., Chaparro D., Borel B., et al. Annals of Physical and Rehabilitation Medicine, 2021, vol. 64, no 4, p. 101453
Bioelectrical impedance analysis for heart failure diagnosis in the ED
Genot N., Mewton N., Bresson D., Zouaghi O., Francois L., Delwarde B., Kirkorian G., Bonnefoy-Cudraz E. The American Journal of Emergency Medicine, 2015, vol. 33, no. 8, p. 1025-1029
Impact d'un programme d'éducation thérapeutique du patient à l'activité physique chez des patients en phase subaiguë d'accident vasculaire cérébral
Kammoun B. Doctoral thesis, University of Limoges
Mobile telemedicine unit serving emergency and chronic care
Moreno M.-V., Chauvet P., Ly O. Intelligent Health & Preventive Medicine International Symposium, Tangier, June 2014
Detection and localization of internal hemorrhaging using electrical impedance
Morse J., Fenech M. Journal of Physics, Conference Series, 2013, vol. 434
Used in emergency departments, BIS has demonstrated its value in the non-invasive diagnosis of heart failure.
Cardiac Remodeling and Its Determinants in Anorexia Nervosa Adolescents: Impact of Weight Recovery
Paysal J., Thireau J., Terral D., Rochette E., Obert P., Merlin E., & Nottin S. Children, 2022, vol. 9, no 4, p. 458
Left Ventricular Strains and Myocardial Work in Adolescents With Anorexia Nervosa
Paysal J., Merlin E., Terral D., Chalard A., Rochette E., Obert P., & Nottin S. Frontiers in Cardiovascular Medicine, 2022, vol. 9
Cardiac repercussions of adolescent weight disorders: Evaluation of left ventricular mechanics and myocardial work
Paysal J. Doctoral thesis, University of Avignon
Effect of individualized coaching at home on walking capacity in subacute stroke patients: A randomized controlled trial (Ticaa'dom)
Mandigout S., Chaparro D., Borel B., et al. Annals of Physical and Rehabilitation Medicine, 2021, vol. 64, no 4, p. 101453
Bioelectrical impedance analysis for heart failure diagnosis in the ED
Genot N., Mewton N., Bresson D., Zouaghi O., Francois L., Delwarde B., Kirkorian G., Bonnefoy-Cudraz E. The American Journal of Emergency Medicine, 2015, vol. 33, no. 8, p. 1025-1029
Impact d'un programme d'éducation thérapeutique du patient à l'activité physique chez des patients en phase subaiguë d'accident vasculaire cérébral
Kammoun B. Doctoral thesis, University of Limoges
Mobile telemedicine unit serving emergency and chronic care
Moreno M.-V., Chauvet P., Ly O. Intelligent Health & Preventive Medicine International Symposium, Tangier, June 2014
Detection and localization of internal hemorrhaging using electrical impedance
Morse J., Fenech M. Journal of Physics, Conference Series, 2013, vol. 434